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What is a Histamine Intolerance Test? What You Need to Know.

Nov 14, 2023

Food intolerance, food allergies, and histamine intolerance – these terms are often used interchangeably, but they represent distinct conditions with varying implications for your health.  

In this blog, we'll understand the differences between them, explore what histamine intolerance is, and discuss why you might need a histamine intolerance test. 

Food Intolerance vs. Food Allergy vs. Histamine Intolerance 

Histamine Intolerance

To understand histamine intolerance, it's essential to differentiate it from food intolerance and food allergies. 

  • Food Allergy:

A food allergy is an immune system response to a specific allergen, often resulting in severe or life-threatening reactions, including anaphylaxis. Allergic reactions typically involve the production of IgE antibodies, which can be detected through skin or blood tests. 
  • Food Intolerance:

Food intolerance, on the other hand, primarily affects the digestive system and manifests as less severe symptoms such as bloating, gas, diarrhoea, or nausea. It's generally caused by the absence or deficiency of specific enzymes needed to digest certain food components, like lactose or gluten, or sensitivity to food additives. Unlike food allergies, food intolerances cannot be diagnosed through blood tests. Instead, identifying food intolerances often involves keeping a food diary, eliminating suspected foods, and reintroducing them to observe symptoms. 

The Complex Nature of Histamine Intolerance 

Histamine intolerance is a unique condition that goes beyond the realm of food allergies and intolerances. While it does involve food, it's not merely about the histamine content in what you eat. Histamine is an essential chemical produced by the immune system to protect the body from potential threats, such as allergens. This crucial molecule is stored in specialized cells called mast cells, scattered throughout various body tissues. 

Histamine acts as a messenger in the body, playing a pivotal role not only in immunity but also in the nervous system. When histamine is released by immune cells like mast cells, it binds to four different types of receptors on other cells. Depending on the receptor it binds to, histamine can trigger various effects, including inflammation, itching, low blood pressure, and bronchoconstriction. While histamine is necessary for the proper functioning of both the immune and nervous systems, it must be regulated. 

Uncontrolled histamine levels can lead to chronic inflammation, which can have detrimental consequences for health. To address symptoms resulting from excessive histamine, antihistamine drugs have been developed. These drugs work by blocking histamine's action, alleviating allergy symptoms. However, they don't address the root cause, which is an excess of histamine. 

For those dealing with histamine intolerance, which occurs when the body can't adequately break down histamine, it's essential to consider alternative approaches. This is where products like our Histamine Control pills come into play. 

Histamine Intolerance: Is a Test Necessary? 

If you suspect you might be experiencing histamine intolerance, you may wonder if a histamine intolerance test is necessary. Histamine intolerance arises when your body accumulates too much histamine, leading to symptoms like digestive issues, headaches, skin rashes, and nasal congestion. 

The root of histamine intolerance often lies in the inadequate function of two enzymes: diamine oxidase (DAO) and histamine N-methyltransferase (HNMT). These enzymes are essential for breaking down histamine in the body. Their malfunction can result from genetic factors, medications, toxins, stress, gut disorders, or the consumption of histamine-rich foods. 

While several methods are used to test for histamine intolerance, none of them are universally reliable or widely accepted by medical professionals. Some of these tests include: 

  • Histamine Provocation Test:

This test involves administering a histamine-containing food or drink and monitoring your body's reaction to determine if you're intolerant. 
  • DAO Measurement:

A blood test checks the level of DAO in your body, the enzyme responsible for breaking down histamine. However, this test is contentious, as DAO levels can fluctuate due to various factors and may not reflect your actual histamine tolerance. 
  • Histamine 50 Prick Test:

This skin test injects a small amount of histamine under your skin, and the reaction size is measured. This test is seldom used and may not be accurate for diagnosing histamine intolerance. 

So, what's the best way to determine if you have histamine intolerance? 

Histamine image

If you suspect histamine intolerance, one effective approach is to undertake an elimination diet. This involves avoiding foods high in histamine or those that trigger histamine release for a few weeks and observing if your symptoms improve. Foods to be cautious of during this period include alcohol, aged cheeses, fermented foods, cured meats, tomatoes, spinach, avocados, citrus fruits, and chocolate. Consulting with your doctor before taking any supplements or medications that might affect histamine levels or DAO activity is also advisable. 

Additionally, you can explore products like our Histamine Control pills, designed to target DAO and HNMT, enhancing their function and supporting healthy histamine balance. If you notice that your histamine intolerance symptoms improve with each dose, it's highly likely that you are dealing with histamine intolerance. 

In conclusion, histamine intolerance is a distinct condition that demands specific attention. While there isn't a foolproof test for histamine intolerance, the symptoms can often be managed through dietary modifications, supplements, and medications targeting histamine-regulating enzymes. If you suspect histamine intolerance, consulting with a healthcare professional is crucial to determine the best course of action for your specific needs. 

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