MTR/MTRR

MTR and MTRR are two genes that encode enzymes involved in the metabolism of homocysteine, a sulfur-containing amino acid. Homocysteine is a byproduct of methionine, an essential amino acid that is involved in many biological processes, such as DNA methylation, protein synthesis, and cellular signaling. MTR and MTRR work together to convert homocysteine back to methionine, using folate and vitamin B12 as cofactors. This process is important for maintaining normal levels of homocysteine in the blood, as high levels of homocysteine are associated with increased risk of cardiovascular disease, neural tube defects, and other health problems.

MTR and MTRR have this particular role to recycle B12 when it is oxidized. Imagine that your B12 is kind of rusted. You need to recycle it to make it un-rusted and available again for methylation. You don't want to waste it in the urine and get a few B12 pills every day. And which B12 would you need? hydroxocobalamin? methylcobalamin ? adenosylcobalamin? We would suggest recycling the cobalamin (B12) instead of supplementing molecules that your body may not need and that could make the situation worse.